Kyrie Irving and Dion Waiters have a chance to become the first two players to score at least 40 points in a game since Tim Duncan and Magic Johnson in 2002-03.
They will be joined by Kyrie’s brother, Josh, who scored a game-high 35 points against the Thunder.
It’s the third time in three days that Irving has scored at least 30 points, his best total since he scored 29 against the Pacers on Dec. 21.
Waiters scored 24 and was the second player in league history to average at least 25 points in three consecutive games.
“We’ve just got to keep working and keep practicing,” Irving said.
The Cavs have won five straight against the Oklahoma City Thunder.
They’re coming off an 86-78 victory in Oklahoma City on Wednesday and are looking to rebound from a tough loss at home to the Brooklyn Nets.
Irving and Waiters combined for 54 points and seven assists, but the Thunder were without All-Star forward Kevin Durant.
Durant had 18 points and 14 rebounds.
“I thought we played a lot of defense,” Durant said.
“We did a good job of holding them to a low percentage, especially when we had them in the paint.
But we also gave up some big offensive rebounds.”
The Cavs scored 34 points in the fourth quarter, their second straight game with double-digit points.
The last time they scored 34 or more in a quarter was Nov. 29 against San Antonio.
They also had a season-high 27 assists.
James was held to four points in 22 minutes while Kyrie scored 21 points in his second game back.
Wait, who has missed the past two games with a strained right calf, was limited in his return from injury.
“[I’m] going to have to go back and work hard to try to get the same production,” James said.
The Thunder (17-13) are in the midst of a three-game road trip.
They face a Cleveland team that was off to a slow start, but is now on pace for a league-best 16-game winning streak.
Kevin Durant scored 21 of his 31 points in one quarter against the Clippers, but Oklahoma City trailed by as many as 21 points after the first quarter.
The Thunder have won four of five and have won six of nine on the road.
Oklahoma City has lost six straight and four of six at home.
After a slow opening three quarters, the Thunder took a 36-23 lead into the fourth.
They finished 11 of 17 from 3-point range, but James had 19 points in each half and had 12 assists.
The Cavs made 14 of 19 shots in the first half and 11 of 20 in the second.
James added 16 points on 6-of-12 shooting in the third.
Thunder coach Scott Brooks said he didn’t want to go into the game saying he would be happy with the way his team played.
“Our starters were not playing well,” Brooks said.
“We are a tough team, we are going to continue to play like that,” Brooks added.
While the Thunder are trying to regain their identity as a contender, they are also trying to win a second straight NBA title, this time for the first time since 1997-98.
Oklahoma won its fourth straight in the series in the 2012-13 season.
The teams last meeting was in the Western Conference semifinals.
Durant and James scored 20 points each in the final minutes.
Durant was 2 for 5 from 3 and made 5 of 11 from the free throw line in the most recent meeting, a 104-98 victory for the Thunder on Feb. 2, 2019.